Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1450 | Pituitary Clinical | ICEECE2012

Asymptomatic nonfunctioning pituitary macroadenomas take advantage of surgery

Dubourg J. , Messerer M. , Daniel R. , Bervini D. , Berhouma M. , Perrin G. , Iype G. , Chacko A. , Trouillas J. , Raverot G. , Jouanneau E.

Introduction: Pituitary incidentalomas (PIs) defined as pituitary tumors discovered by systematic neuroimaging constitute an increasingly clinical problem. Most of PIs are nonfunctioning tumors (NFPIs) with systematic investigation revealing visual and/or endocrinological impairment in some patients while others remained asymptomatic. If the therapeutic management is well codified for functioning PIs and symptomatic NFPIs, a debate still remain for asymptomatic NFPIs between s...

ea0092op-05-05 | Oral Session 5: Young Investigators / Basic | ETA2023

Distinguishing beneficial local from adverse systemic thyroid hormone action in alcoholic liver disease

Hoppe Christoph , Sebastian Hones G. , Siemes Devon , Wenzek Christina , Flamant Frederic , Gauthier Karine , Engel Daniel R. , Zwanziger Denise , Lange Christian M. , Baba Hideo , Fuhrer-Sakel Dagmar , Christian Moller Lars

Thyroid hormones (TH) reduce liver steatosis. As steatosis is the initial step of alcoholic liver disease (ALD), we hypothesized that TH treatment could ameliorate ALD. Wildtype (WT) mice were treated with either ethanol (EtOH) or liquid control diet for 10 days followed by a single EtOH or maltose binge on day 11. In both groups, diet was supplemented with either T3 or solvent. Serum triglycerides (TG) were increased by EtOH and, surprisingly, further elevated by T3. Liver we...